TGFβ superfamily-dependent and osmolarity-mediated type II collagen expression by chondrocytes in vitro
نویسندگان
چکیده
منابع مشابه
Looping Mediated Interaction between the Promoter and 3′ UTR Regulates Type II Collagen Expression in Chondrocytes
Type II collagen is the major component of articular cartilage and is mainly synthesized by chondrocytes. Repeated sub-culturing of primary chondrocytes leads to reduction of type II collagen gene (Col2a1) expression, which mimics the process of chondrocyte dedifferentiation. Although the functional importance of Col2a1 expression has been extensively investigated, mechanism of transcriptional ...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Translation
سال: 2016
ISSN: 2214-031X
DOI: 10.1016/j.jot.2016.06.198